منابع مشابه
The Synovium in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune disease targeting multiple joints. The synovium is the primary site of the inflammatory process, which if untreated leads to irreversible damage to the adjacent cartilage and bone. It is now well established that autoantibodies that are characteristic of RA, including rheumatoid factor (RF) and anti-citrulluninated protein antibodies (ACPA), are...
متن کاملAutoimmune Responses in the Rheumatoid Synovium
Perspective R heumatoid arthritis (RA) is a chronic inflammatory disorder affecting joints, often with severe and disabling consequences. Although cells and intracellular signals characterizing inflamed tissue in RA are not qualitatively different from those found in other conditions, in about one third of patients with RA ectopic lymphoid structures can be found in affected tissue [1]. These s...
متن کاملRheumatoid arthritis synovium contains plasmacytoid dendritic cells
We have previously described enrichment of antigen-presenting HLA-DR+ nuclear RelB+ dendritic cells (DCs) in rheumatoid arthritis (RA) synovium. CD123+HLA-DR+ plasmacytoid DCs (pDCs) and their precursors have been identified in human peripheral blood (PB), lymphoid tissue, and some inflamed tissues. We hypothesized recruitment of pDCs into the inflamed RA synovial environment and their contribu...
متن کاملThe gene delivery system for rheumatoid synovium.
A gene therapy of synovial tissue is potentially a novel therapeutic method in rheumatoid arthritis (RA). The method induces expression of anti-arthritic molecules in target cells, and is also useful for the investigation of novel therapeutic targets in vitro. Previous studies showed that viral vectors, which can infect non-proliferative cells well, i.e. adenovirus-based vector, were effective ...
متن کاملCorrection: Cells of the synovium in rheumatoid arthritis. Chondrocytes
After publication of our recent article [1], we noticed an error in the third sentence of the third paragraph of the section entitled, 'Joint inflammation and cartilage remodeling in RA'. This sentence should read: ADAMTS-5 is expressed constitutively, whereas ADAMTS-4 is more prominently regulated by inflammatory cytokines.
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1970
ISSN: 0003-4967
DOI: 10.1136/ard.29.6.653